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Colgate Total<sup>®</sup> Advanced Pro‑Shield<sup>™</sup> Mouthwash

Colgate Total® Advanced Pro‑Shield™ Mouthwash

An alcohol-free formula that provides patients with 12 hours of antibacterial protection, even after eating and drinking*

* Results improve with continued twice-daily use.

Ingredients

Active ingredients

Cetylpyridinium Chloride 0.075% (Antigingivitis/Antiplaque)

Inactive ingredients

Water, Glycerin, Propylene Glycol, Sorbitol, Poloxamer 407, Flavor, Potassium Sorbate, Citric Acid, Sodium Saccharine, FD&C blue no. 1.

Mode of Action

Colgate Total® Advanced Pro-Shield™ Mouthwash contains 0.075% Cetylpyridinium Chloride (CPC), an FDA-approved active ingredient that helps prevent and reduce plaque and gingivitis.

Proof of Efficacy
  • 12 hours of antibacterial protection, even after eating and drinking1
  • Kills 99% of bacteria on contact2
  • A pre-procedural rinse that helps significantly reduce the number of aerosolized bacteria
  • Helps reduce plaque and gingivitis,3,4,5

A clinical study to assess the 12-hour antimicrobial effects of cetylpyridinium chloride mouthwashes on supragingival plaque bacteria

He S, Wei Y, Fan X, Hu D, Sreenivasan PK.

Results: Subjects rinsing with the CPC-containing mouthwash realized a statistically significant (p< 0.05) reduction in numbers of supragingival anaerobic bacteria at the 12-hour evaluation after a single use. In comparison to the control mouthwash, use of the CPC mouthwash in an alcohol base resulted in a 35.3% reduction in numbers of anaerobic plaque bacteria, while the CPC mouthwash in an alcohol-free base demonstrated a 34.5% reduction. Further, the analysis after twice-daily use for 14 days indicated that the CPC mouthwash in an alcohol base demonstrated a 73.8% reduction in anaerobic plaque bacteria, while the CPC mouthwash in an alcohol-free base demonstrated a 70.9% reduction in anaerobic plaque bacteria versus the control mouthwash.

References:

1. Data on file. Colgate-Palmolive Company. May 2013.
2. Data on file. Colgate-Palmolive Company. May 2013. Results improved with continued twice daily use.
3. Data on file. Colgate-Palmolive Company. December 2012.
4. Data on file. Colgate-Palmolive Company. December 2012.
5. Data on file. Colgate-Palmolive Company. June 2013.

Drug Facts

Active Ingredient: Active Ingredients: Cetylpyridinium Chloride (0.075%).

Purpose: Antigingivitis/Antiplaque.

Use: Helps prevent and reduce plaque and gingivitis.

Warnings: Ask a dentist if condition persists or worsens after regular use. Keep out of reach of children under 6 years of age. If more than used for rinsing is accidentally swallowed, get medical help or contact a Poison Control Center right away. Cap sealed with printed band.

Directions: Adults and Children 12 Years of Age and Older: Rinse for 30 seconds with 20 ml (4 teaspoonfuls) twice a day. Do not swallow. Children 6 Years to under 12 Years of Age: Supervise use. Children Under 6 Years of Age: Do not use.

Inactive Ingredients: Water, Glycerin, Propylene Glycol, Sorbitol, Poloxamer 407, Flavor, Potassium Sorbate, Citric Acid, Sodium Saccharin, FD&C Blue 1.

Questions? 1-800-468-6502